Bioactivity-guided separation of potential α-glycosidase inhibitor from clerodendranthus spicatus based on HSCCC coupled with molecular docking
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چکیده
منابع مشابه
Bioactivity-Guided Separation of an α-Amylase Inhibitor Flavonoid from Salvia virgata
It is now believed that the inhibition of carbohydrate hydrolyzing enzymes (CHEs) in the digestive tract can significantly prolong the overall carbohydrate digestion time and decrease the postprandial hyperglycemia after a meal. Therefore, inhibitors of CHEs can be useful therapeutic approaches in the management of diabetes mellitus, especially in the type 2, and complications associated with t...
متن کاملBioactivity-Guided Separation of an α-Amylase Inhibitor Flavonoid from Salvia virgata
It is now believed that the inhibition of carbohydrate hydrolyzing enzymes (CHEs) in the digestive tract can significantly prolong the overall carbohydrate digestion time and decrease the postprandial hyperglycemia after a meal. Therefore, inhibitors of CHEs can be useful therapeutic approaches in the management of diabetes mellitus, especially in the type 2, and complications associated with t...
متن کاملbioactivity-guided separation of an α-amylase inhibitor flavonoid from salvia virgata
it is now believed that the inhibition of carbohydrate hydrolyzing enzymes (ches) in the digestive tract can significantly prolong the overall carbohydrate digestion time and decrease the postprandial hyperglycemia after a meal. therefore, inhibitors of ches can be useful therapeutic approaches in the management of diabetes mellitus, especially in the type 2, and complications associated with t...
متن کاملNew ursane-type triterpenoids from Clerodendranthus spicatus.
Five new ursane-type triterpenoids, spicatusoids A-E (1, 3-6), and three known ones (2, 7, and 8), and a known oleanane-type triterpenoid (9) were isolated from the aerial parts of Clerodendranthus spicatus. Their structures were elucidated by spectroscopic methods. In particular, the structure of 3 including its absolute configuration was confirmed by single-crystal X-ray diffraction analysis....
متن کاملBioactivity-Guided Separation of an α-Amylase Inhibitor Flavonoid from Salvia virgata
It is now believed that the inhibition of carbohydrate hydrolyzing enzymes (CHEs) in the digestive tract can significantly prolong the overall carbohydrate digestion time and decrease the postprandial hyperglycemia after a meal. Therefore, inhibitors of CHEs can be useful therapeutic approaches in the management of diabetes mellitus, especially in the type 2, and complications associated with t...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: 2045-2322
DOI: 10.1038/s41598-021-86379-9